Recent studies have indicated that birth weight to placental weight (BW/PW) ratio is related to perinatal outcomes, but the effect of congenital abnormalities on BW/PW ratio remains unclear. We performed this study to elucidate correlations between BW/PW ratio and congenital abnormalities. Subjects were 735 singleton infants born at 34–41 weeks of gestation admitted to our center between 2010 and 2016. Of these, 109 infants (15%) showed major congenital anomalies. Major congenital anomalies and subgroups were diagnosed according to European Surveillance of Congenital Anomalies criteria. The primary outcome was the association between BW/PW ratio and major congenital anomaly, and secondary outcomes were the distribution pattern of BW/PW ratio with major anomalies and by major anomaly subgroups in each categorization (<10th percentile, 10–90th percentile, or >90th percentile) of BW/PW ratio. BW/PW ratio was not associated (P = 0.20) with presence (adjusted mean BWPW ratio = 5.02, 95% confidence interval [CI] 4.87–5.18) or absence (adjusted mean BW/PW ratio = 4.91, 95%CI 4.85–4.97) of major anomalies, after adjusting for gestational age and sex. Proportions of infants with major anomalies according to BW/PW ratio categories were as follows: 12% in <10th percentile, 15% in 10–90th percentile, and 25% in >90th percentile of BW/PW ratio. Among major anomalies of the nervous system, congenital heart defects, and orofacial clefts, BW/PW ratio showed equally distributed trend across the three BW/PW ratio categories, but showed unequally distributed trend for anomalies of the digestive system, other anomalies/syndromes, or chromosomal abnormalities. BW/PW ratio was not associated with major congenital anomaly, and was distributed diffusely according to major anomaly subgroups. Major anomalies may tend to aggregate in the 90th percentile of the BW/PW ratio.
Citation: Takemoto Roentgen, Anami A beneficial, Koga H (2018) Relationship between birth pounds so you can placental pounds ratio and big congenital defects inside the The japanese. PLoS You to definitely thirteen(10): e0206002.
Copyright: © 2018 Takemoto ainsi que al. This is exactly an open access blog post marketed underneath the regards to the fresh new Creative Commons Attribution Permit, and that permits unrestricted use, shipping, and you may reproduction in almost any average, offered the original writer and supply are credited.
Relationships anywhere between beginning pounds to help you placental pounds proportion and you can significant congenital defects in Japan
Abbreviations: BW, Birth lbs; BW/PW proportion, delivery lbs to help you placental pounds https://datingranking.net/nl/blendr-overzicht/ proportion; NICU, neonatal extreme care and attention product; PW, placental pounds
Addition
As the 1990s, experts was shopping for placental weight (PW), and have said connectivity between PW and you can perinatal consequences [1,2] and also the development of ailment into the mature lifetime . Eutherian (placental) animals reveal a close relationship ranging from PW and you will fetal growth, and full-identity delivery lbs (BW) away from people, pigs and you may goats is approximately five times the latest PW [4–6]. People PWs and complete-identity BWs vary by over fifteen% ranging from more races or countries [4,7,8]. Yet not, a full-identity BW-to-PW (BW/PW) proportion is proven to simply disagree by below 5% ranging from ethnicities or nation regarding delivery [4,seven,9]. This means that that BW/PW ratio may offer a valuable in the world perinatal index. A relatively large BW/PW ratio means not enough placental fresh air also provide towards the fetus. Alternatively, a minimal BW/PW ratio suggests a great suboptimal fetal status. Past research has showed connectivity away from BW/PW proportion having perinatal consequences , risk of emotional palsy and you may condition outcomes inside after that adulthood . Whether or not congenital defects could affect fetal gains , the connection ranging from congenital defects and you may PW possess yet is elucidated [fourteen,15]. We hypothesized you to definitely fetal congenital anomaly may lead to a low BW/PW proportion on account of fetal growth restriction, or to a premier BW/PW proportion on account of inappropriate fetal over growing. We examined whether contacts existed ranging from BW/PW ratio and you can biggest congenital defects and the big anomaly subgroups.